A person with peripheral artery disease (PAD) may have little to no symptoms initially, but over time, may develop critical limb ischemia (CLI).
CLI is an advanced stage of PAD, this progressive condition occurs when there is significant blockage in the arteries, which reduces blood flow to areas such as the legs and feet.1
The lack of blood flow can lead to severe pain, even when at rest during the night, non-healing wounds below the ankle, gangrene and ultimately limb amputation.
Without proper and immediate treatment, patients with CLI may risk amputation and related complications.2
Approximately 12 percent of the population has CLI, but many are still unaware.5